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Drug Targeting and Design Methodologies

Drug Targeting and Design Methodologies

The target drug targeting and design delivery system is a special form of drug delivery system in which the pharmacologically active agent or drug is selectively targeted or delivered only to its site of action or uptake and not to organs, non-target tissues or cells. Targeted drug delivery involves the selective and efficient localization of a pharmacologically active moiety on a pre-identified or preselected therapeutic target while limiting its access to normal non-targeted cell liners, …

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The Relationship Between Pharmacokinetics and Pharmacodynamics

The Relationship Between Pharmacokinetics and Pharmacodynamics

The Origins and Definition Pharmacokinetics (PK) is a term that is derived from two words pharmakon referring to pharmaceutical drugs and kinetics whose meaning is to imply movement. Pharmacokinetics has also been traditionally understood to refer to the study of the movement of drugs within the body. The main aspects described in the studies involving pharmacokinetics are commonly called ADME or absorption, distribution, metabolism, and excretion of drugs. The combined metabolism and excretion components define …

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APIs and Pharmaceutical Formulations – Different, but Essential Ingredients of Drugs

APIs and Pharmaceutical Formulations – Different, but Essential Ingredients of Drugs

APIs, what are they? Active Pharmaceutical Ingredients, otherwise known as APIs are the essential chemical ingredients of any drug that result in its effects. Some medicines, such as combination therapies, contain several active ingredients to treat different symptoms or to act in different ways. The production of APIs is traditionally entrusted to the pharmaceutical companies themselves in their country of origin. But in recent years, numerous companies have chosen to relocate their manufacturing plants abroad, …

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What is a small molecule drug?

What is a small molecule drug?

A small molecule drug is an organic compound with a molecular weight below 900 Daltons that affect a biologic process, but any healthcare investor’s understanding should go far beyond this definition. Small molecules are low molecular weight molecules that include lipids, monosaccharide’s and other natural products and metabolites, as well as drug and other xenobiotics. They are distinct from macromolecules such as proteins. In chemical biology, this term also covers metal ions and in this …

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Drug Side Effects

Drug Side Effects

Drug side effects are generally regarded as an unhealthy secondary effect, which leads to the desired remedial effect of medicine or medication. The side effects of drugs vary for everyone depending on the person’s disease status, age, weight, gender, ethnicity, and general health. Side effects can be triggered when degradation/increasing dose or drug or drug system expires. Side effects can also not follow with the proposed treatment. When the side effects of the drug or …

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